Heart: The heart can increase in size as a result of physical exercise, long-standing high blood pressure, obstruction to blood flow out of the heart, or genetic conditions that affect the growth of muscle cells in the heart.This allows the uterus to grow along with the developing baby. Uterus: The muscles in the uterus undergo hypertrophy during pregnancy.This makes the muscles stronger and better able to handle physical stress. Pathological hypertrophy is also observed in primary hypertrophic cardiomyopathy which is an autosomal dominant disease that affects that contractile proteins. Muscles: Physical exercise leads to skeletal muscle hypertrophy.Interaction between cardiomyocytes and non-cardiomyocytes modulates cardiomyocyte hypertrophy. Pathological hypertrophy develops myocytes death and fibrotic remodeling, and this promotes cardiac dysfunction. Hypertrophy is described as pathologic when it is caused by disease or leads to impaired function. Pathological and physiological hypertrophy differs in the signaling pathways that drive these processes. Hypertrophy is described as physiologic when it helps or improves the way the organ or tissue functions. For example, increase in the size of the heart due to aortic stenosis. During pregnancy, the muscle cells in the uterus undergo hypertrophy in response to increased hormone stimulation. Pathologic hypertrophy: Occurs due to an abnormal stressor. Skeletal and cardiac muscle cells commonly undergo hypertrophy in response to increased physical demand and stress on the cells. In contrast to hyperplasia, hypertrophy does not result in an increased number of cells. Another word for hypertrophy is hypertrophic. Hypertrophy is an increase in the size of cells that leads to an overall increase in the size of the tissue or organ.
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